Vysis® Wolf-Hirschhorn Region Probe - LSI® WHS SpectrumOrange/CEP® 4 SpectrumGreenTM

3765_4083
Wolf-Hirschhorn Region Probe - LSI WHS SpectrumOrange/CEP 4 SpectrumGreen

Product Description

Probe Name Probe Location Fluorophore
Vysis LSI WHS 4p16.3  SpectrumOrange TM
Vysis CEP 4 4p11.1-q11.1 Alpha Satellite DNA SpectrumGreen TM
The Wolf-Hirschhorn (WHS) probe set targets p arm of chromosome 4.

The LSI WHS probe is directly labeled with SpectrumOrange and is mixed with a control probe, CEP 4 labeled with SpectrumGreen fluorophore.

Probe Map



 

Metaphase spread containing one chromosome 4 with the CEP 4 SpectrumGreen but without the LSI WHS SpectrumOrange signal.The normal chromosome 4 shows the presence of the LSI WHS SpectrumOrange and the CEP 4 SpectrumGreen.

References

  1. Hirshhorn, K., et. al., Deletion of Short Arms of Chromosome 4-5 in a child with defects of midline fusion. Humangenetik, 1: 479-482, 1965.
  2. Estabrooks, L.L. et. al., Preliminary Phenotypic Map of Chromosome 4p16 Based on 4p Deletions. Am J. Med. Genet., 57; 581-586, 1995.
  3. Altherr, M. R. et. al Molecular Confirmation of Wolf-Hirschhorn Syndrome with a Subtle Translocation of Chromosome 4. Am. J. Hum. Genet., 49: 1235-1242, 1991.
  4. Ingrid, S., et. al., WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IGH in t (4;14) multiple myeloma. Human Molecular Genetics, 7:1, 1071-1082, 1998.
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Order Information

Product Name Package Size Vysis Order Number Abbott Order Number
Vysis Wolf-Hirschhorn Region Probe - LSI WHS SpectrumOrange/CEP 4 SpectrumGreen  20 µL 32-190074 05J29-074
5J29
Analyte Specific Reagent.
Analytical and performance characteristics are not established.