Vysis Smith-Magenis Region Probe - LSI SMS Region SpectrumOrange/LSI RARA SpectrumGreen
Product Description
| Probe Name | Probe Location | Fluorophore |
| Vysis LSI SMS | 17p11.2 | SpectrumOrange TM |
| Vysis LSI RARA | 17q12-21 | SpectrumGreen TM |
LSI SMS is approximately 140 kb in size and homologous to the Smith-Magenis region. The LSI SMS probe is directly labeled with SpectrumOrange and is mixed with the LSI RARA control probe. LSI RARA is specific to 17q21.1 and is directly labeled with SpectrumGreen.
Probe Map
Metaphase spread containing one chromosome 17 with the SpectrumGreen SpectrumGreen the SpectrumOrange LSI SMS Probe signal. The normal chromosome 17 shows the presence of the SpectrumOrange LSI SMS Probe and the SpectrumGreen LSI RARA Control Probe.
References
- Juyal, R.C., et. al. Molecular Analyses of 17p11.2 Deletions in 62 Smith-Magenis Syndrome Patients, Am. J. Hum. Genet. 58:998-1007, 1996.
- Zori, R.T. et. al. Clinical, Cytogenetic, and Molecular Evidence for an Infant With Smith-Magenis Syndrome Born From a Mother Having Mosaic 17p11.2p12 Deletion, Am. J. Med. Genet. 47:504-511, 1993.
- Schmickel, R.D. Contiguous gene syndromes: a component of recognizable syndromes. J. Pediat 109:231-241 1986.
- Elsea, S..H., et. al. Haploinsufficiency of Cystolic Serine Hydroxymethyltransferase in the Smith-Magenis Syndrome. Am. J. Med. Genet. 57:1342-1350, 1995.
- Cambell, H.D., et. al. Genomic Structure, Evolution, and Expression of Human FLII, a Gelsolin and Leucine-Rich-Repeat Family Member: Overlap with LLGL. Genomics 42:46-54, 1997.
- Elsea, S.H., et. al. Gene for Topoisomerase III Maps within the Smith-Magenis Syndrome Critical Region: Analysis of Cell-Cycle Distribution and Radiation Sensitivity. Am. J. Med. Genet. 75:104-108, 1998.
Analyte Specific Reagent.
Analytical and performance characteristics are not established.
Analytical and performance characteristics are not established.
