Vysis Miller-Dieker Region/Isolated Lissencephaly Probe LSI LIS1 SpectrumOrange/LSI RARA SpectrumGreen

3765_4083
Miller-Dieker Region/Isolated Lissencephaly Probe LSI LIS1 SpectrumOrange/LSI RARA SpectrumGreen

Product Description

Probe Name Probe Location Fluorophore
Vysis LSI LIS 1 17p13.3  SpectrumOrange TM
Vysis LSI RARA 17q21.1  SpectrumGreen TM
The Vysis® LSI LIS1 FISH probe is approximately 110 kb in size and homologous to the LIS1 gene located at 17p13.3. The LSI LIS1 probe is directly labeled with SpectrumOrange and is mixed with a control probe, LSI RARA. LSI RARA is specific to the 17q21.1 region and is directly labeled with SpectrumGreen fluorophore.

Probe Map



 

Metaphase spread containing one chromosome 17 with SpectrumGreen LSI RARA and absence of the SpectrumOrange LSI LIS1 signal (arrow). The normal chromosome 17 shows the presence of SpectrumOrange LSI LIS1 and SpectrumGreen LSI RARA.

References

  1. Ledbetter, S. A. et. al. Microdeletions of Chromosome 17p13 as a Cause of Isolated Lissencephaly, Am. J. Hum. Genet.50:182-189, 1992.
  2. Dobyns, W. B. et. al. Clinical and Molecular Diagnosis of Miller-Dieker Syndrome, Am. J. Hum. Genet. 48:584-594, 1991.
  3. Van Zelderen-Bhola, S.L et. al. Prenatal and Postnatal Investigation of a Case with Miller-Dieker Syndrome Due to a Familial Cryptic Translocation t(17;20)(p13.3;q13.3) Detected by Fluorescence In Situ Hybridization, Prenatal Diagnosis 17:2:173-179, 1997.
  4. Kuwano, A. et. al. Detection of Deletions and Cryptic Translocations in Miller-Dieker Syndrome by In Situ Hybridization, Am. J. Hum.Genet. 49:707-714,1991.
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Order Information

Product Name Package Size Vysis Order Number Abbott Order Number
Vysis Miller-Dieker Region/Isolated Lissencephaly Probe LSI LIS1 SpectrumOrange/LSI RARA SpectrumGreen   20 µL 32-190065 05J88-001
5J88
Analyte Specific Reagent.
Analytical and performance characteristics are not established.