Vysis^® LSI^® p53 (17p13.1) SpectrumOrange^TM Probe

Product Description

Probe Name	Probe Location	Fluorophore
Vysis LSI TP53	17p13.1	SpectrumOrange ^TM

The LSI TP53 (previously designated as p53) Probe maps to the 17p13.1 region on chromosome 17 containing the p53 gene. The ability to use FISH probes such as the LSI p53 (17p13.1) for interphase cytogenetics has provided new insights into chromosomal aberrations. This probe may be used to detect the deletion (not mutation) or amplification of the p53 locus.

The LSI p53 (17p13.1) SpectrumOrange Probe is an approximately 145 kb probe.

Probe Map

Results of Hybridization

In a cell containing a deletion of the LSI p53 locus, one orange LSI p53 signal will be observed (1O signal pattern). In a cell harboring amplification of the p53 locus multiple copies of the orange signal will be observed. In a normal cell the two orange (2O) signal pattern is observed.

LSI p53 Probe hybridized to a normal cell showing the two orange (2O) signal pattern.

References

Heim, S. & Mitelman, F. (1995) Cancer Cytogenetics 2nd ed. New York City, NY, JohnWiley & Sons, Inc.

Order Information

Product Name	Status	Package Size	Vysis Order Number	Abbott Order Number
Vysis LSI p53 (17p13.1) SpectrumOrange Probe	ASR	20 µL	32-190008	05J52-001 5J52
Vysis LSI p53 (17p13.1) SpectrumOrange Probe		20 µL	32-162008	08L64-020 8L64

Analyte Specific Reagent.
Analytical and performance characteristics are not established.

CE Marked Not available in United States