Vysis® LSI® FKHR (13q14) Dual Color, Break Apart Rearrangement Probe
Product Description
| Probe Name | Probe Location | Fluorophore |
| Vysis LSI FKHR | 13q14 | SpectrumOrange TM SpectrumGreen TM |
The LSI FKHR (13q14) Dual Color, Break Apart Rearrangement Probe consists of a mixture of two FISH DNA probes. The first probe, a 720 kb probe labeled in SpectrumGreen lies proximal to the FKHR gene. The second probe labeled in SpectrumOrange extends distally from the FKHR gene and is approximately 650 kb in length.
Probe Map
Results of Hybridization
In a normal cell that lacks a t(13q14) in the FKHR gene region, a two fusion signal pattern will be observed.
Result of the hybridization of the LSI FKHR (13q14) Dual Color Break Apart Rearrangement Probe, showing the two fusion signal pattern as observed in normal interphase cells.
Abnormal cells hybridized with the LSI FKHR (13q14) Dual Color Break Apart Rearrangement Probe. The cells in this image show the one fusion, one orange and one green signal pattern indicative of a rearrangement of one copy of the FKHR gene region.
Abnormal cells hybridized with the LSI FKHR (13q14) Dual Color Break Apart Rearrangement Probe. The cells in this image show the one fusion, one orange and one green signal pattern indicative of a rearrangement of one copy of the FKHR gene region. In addition, there are often extra signals in the abnormal cases suggesting that perhaps they are also highly aneuploid or polyploidy.
References
- Anderson, J., et al. Br J Cancer 85 (6) (2001): 831-835.
- Biegel, et al.Genes Chrom Cancer 12 (3) (1995): 186-192.
- Slominski, A., et al. Arch Pathol Lab Med. 123 (1999): 1246-1259.
- Womer, R. B., Eur J of Cancer 33 (13) (1997): 2230-2236.
Analyte Specific Reagent.
Analytical and performance characteristics are not established.
Analytical and performance characteristics are not established.
