Vysis® LSI® ATM (11q22.3) SpectrumOrangeTM Probe

5611_6294
LSI ATM (11q22.3) SpectrumOrange Probe

Product Description

Probe Name Probe Location Fluorophore
Vysis LSI ATM 11q22.3  SpectrumOrange TM
The LSI ATM probe is a ~500 kb unique sequence probe that hybridizes to the 11q22.3 region of chromosome 11. This probe spans the entire ~184 kb Ataxia telangiectasia mutated (ATM) gene and several others.

Probe Map



Results of Hybridization

This probe set allows status assessment of the ATM gene region on chromosome 11q22.3. In a normal cell with two intact copies of the ATM gene region, a two orange signal pattern will be observed. In an abnormal cell with a deletion in the ATM gene region, fewer than two orange signals will be observed.

Result of the hybridization of the LSI ATM (11q22.3) Probe as observed in a normal interphase cell.
Abnormal cell hybridized with the LSI ATM (11q22.3) Probe. The cell in this image shows the one orange signal pattern indicative of a deletion of one copy of the ATM gene region on chromosome 11q22.3.

References

  1. Anastasi, J., et al. Blood 79 (1992): 1796-1801.
  2. Dohner, H., et al. New Eng Jour Med 343 (2000): 1910-1916.
  3. Bennarji, R., Byrd, J.C. Curr Opin Oncol 12 (2000): 22-29.
  4. Stilgenbauer, S., et al. Leukemia 16 (6) (2002): 993-1007.
  5. Pettitt, A.R., et al. Blood 98 (3) (2001): 814-822.
  6. Stankovic, T., et al. Blood 99 (1) (2001): 300-309.
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Order Information

Product Name StatusPackage Size Vysis Order Number Abbott Order Number
Vysis LSI ATM (11q22.3) SpectrumOrange Probe  ASR 20 µL 32-190017 05J64-001
5J64
Vysis LSI ATM (11q22.3) SpectrumOrange Probe  20 µL 32-160017 01N33-020
1N33
Analyte Specific Reagent.
Analytical and performance characteristics are not established.

CE Marked Not available in United States