FISH: Prenatal, Postnatal and Preimplantation
Identification and characterization of chromosome anomalies in preimplantation, prenatal, and postnatal genetics is critical for predicting IVF cycle and pregnancy outcome, and future quality of life. FISH is a powerful tool for determining many types of chromosome anomalies. In addition to AneuVysion, the only FDA-cleared product for rapid detection of aneusomy in amniotic fluid samples, Abbott Molecular offers an expansive line of Vysis® DNA FISH probes for preimplantation, prenatal, and postnatal genetic testing and research.
Abbott Molecular FISH tests provide the following advantages:
- Rapid, sensitive, and specific detection and characterization of chromosome abnormalities.
- Ability to test metaphase chromosomes from cultured samples and interphase cells from specimens that cannot be cultured.
- Direct-labeled probes, as compared to indirect labeling methods, mean:
- Less background signal, thereby simplifying interpretation.
- Reduced costs associated with labeling reagents and technician time.
- Dual colored probes for most microdeletions.
All products, except where indicated, are Analyte Specific Reagents.Analytical and performance characteristics are not established. Storage Conditions: -20°C for all DNA products. Protect from exposure to direct light.Assay: Defined as a 22 x 22mm target area (half of a 44mm slide) unless otherwise noted. Ideograms are provided to show approximate region of probe hybridization on the chromosome.Drawings of the genes and loci contained in a chromosome region (maps) are intended to show the approximate region of probe coverage and are not necessarily drawn to scale. The region of probe coverage is indicated by a colored bar along the bottom of the map.
Note:Vysis FISH probes are formulated with appropriate concentrations of blocking DNA to provide optimal performance in a variety of specimen types. Some probes (as indicated) are provided pre-mixed in Hybridization Buffer and may be pre-denatured.
